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| Vancomycin Resistance Genes in Various Organisms- An Insilico Study
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Full
text: |
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Source |
International Journal of Biometrics and Bioinformatics (IJBB) |
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Table of Contents |
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Complete Issue PDF(5.66MB) |
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Volume: 5 Issue: 2 |
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Pages: 28-148 |
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Publication
Date: May / June 2011 |
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ISSN
(Online): 1985-2347 |
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Pages |
111 - 129 |
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Author(s) |
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Published
Date |
31-05-2011 |
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Publisher |
CSC
Journals, Kuala Lumpur,
Malaysia |
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ADDITIONAL
INFORMATION |
| Keywords Abstract References Cited by Related Articles Collaborative
Colleague |
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KEYWORDS: Vancomycin Resistant Genes, Sequence Analysis, Enterococci sp., Plasmodium sp. |
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Abstract
Glycopeptide antibiotics are widely used to treat many serious infections caused by gram positive bacteria particularly, methicillin resistant Enterococci and Staphyllococcus sp. Emergence of commonly acquired resistance in bacterial pathogens has lead to clinical complications and threat to human health. The resistance in these organisms is conferred by several Van genes like VanA, VanB, VanD, VanC and VanM. Knowledge of presence of Van genes in various organisms was felt necessary prior to molecular investigation. Therefore, in this insilico study the DNA sequence information was used and screening was carried out for Van gene sequences. Results indicate that many pathogenic and non-pathogenic bacteria, fungal, viral and protozoan pathogens, other organisms like fishes, mammals possess Van like sequences. The present findings provide first hand information on extent of Vancomycin antibiotic resistance in many organisms and emphasize further investigation of the significance of these genes using molecular and bioinformatics tools to help minimize human sufferings.
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| 1 |
S.Mendez-Alvarez,Xiomara, Perez-Hernandez,F.Claverie-Martín, “Glycopeptide resistance in Enterococci” , Internatl Microbiol , Vol. 3,pp.71–80, 2000.
|
|
|
| 2 |
Reynolds. P.E, “Structure, Biochemistry and Mechanism of Action of glycopeptide antibiotics”,Eur.J.clin.Microbiol.Infect.Dis., Vol. 8(11),pp.943-950,1989.
|
|
|
| 3 |
R.Leclercq, E.Derlot., J.Duval, P.Courvalin, “Plasmid-mediated resistance to Vancomycin and teicoplanin in Enterococcus faecium”. N Engl J Med. Vol. 21,319(3),pp157– 161, 1988.
|
|
|
| 4 |
A.H.Uttley, C.H.Collins, J .Naidoo, and R.C.George., “Vancomycin resistant enterococci”, Lancet , Vol. 1, no. 8575-76, pp. 57-58. 1988.
|
|
|
| 5 |
D.F.Sahm, J.Kissinger, M.S.Gilmore, P.R.Murray, R. Mulder, J. Solliday, and B. Clarke, “In vitro susceptibility studies of Vancomycin resistant Enterococcus faecalis” , Antimicrob. Agents Chemother, Vol.33,pp.1588-1591, 1989.
|
|
|
| 6 |
N.Fujita, M. Yoshimura, T. Komori, K.Tanimoto, and Y. Ike, “First report of the isolation of high-level Vancomycin-resistant Enterococcus faecium form a patient in Japan”,Antimicrob Agents Chemother., Vol.42(8),2150, 1998.
|
|
|
| 7 |
Y.Ozawa, K .Tanimoto ,T Nomura, M.Yoshinaga, Y.Arakawam, and Y. Ike, “Vancomycinresistant Enterococci in humans and imported chickens in Japan”. AppI. Environ. Microbiol., Vol.68, pp.6457-6461, 2002.
|
|
|
| 8 |
X.Xu , D.Lin., G.Yan., X.Ye, S.Wu., Y .Guo., D.Zhu, F.Hu, Y.Zhang, F.Wang., G.A.Jacoby and M.Wang, “VanM, a New Glycopeptide Resistance Gene Cluster Found in Enterococcus faecium”, Antimicrobial Agents and Chemotherapy, pp.4643-4647, Vol.54, No. 11. 2010.
|
|
|
| 9 |
B.H. Zheng, Y.H.Tomita, S .Xiao,.Y.Wang. Y.Li and Y.Ike. “Molecular characterization of Vancomycin-resistant Enterococcus faecium isolates form mainland China,” J.Clin. Microbiol , Vol.45, pp.2813-2818,2007
|
|
|
| 10 |
K.Hiramatsu, H.Hanaki, T.Ino, K .Yabuta, T.Oguri and F.C .Tenover, “Methicillin-resistant Staphylococcus aureus clinical strain with reduced Vancomycin susceptibility”, J.Antimicrob. Agents chemother, Vol. 40,pp.135-136, 1997.
|
|
|
| 11 |
F.D.Lowry,“Stophylococcus aureus infections”,New Engl J Med.,Vol. 339,pp.520-532, 1998.
|
|
|
| 12 |
H.K.Tiwari and M.R.Sen , “Emergence of Vancomycin resistant Staphylococcus aureus(VRSA) from tertiary care hospital from northern part of India”,BMC Infectious diseases, Vol.6,156, 2006.
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|
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| 13 |
C.G.Unkal and B.B.Kaliwal, “Vancomycin resistant Staphylococcus aureus containing Van A gene isolated from clinical samples of community health care centres of North Karnataka,India”.,In Proceedings of ISBT held at Shillong, India,pp.464-469, 28th- 30, Dec 2008.
|
|
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| 14 |
P.Courvalin,“Vancomycin resistance in gram-positive cocci”, Clin Infect.,Dis Vol. 42(suppl 1),pp.S25-S34, 2006.
|
|
|
| 15 |
R.Quintiliani, Jr., S. Evers, and P. Courvalin, “The Van B confers various levels ofselftransferable resistance to Vancomycin in enterococci”.J.Infect.Dis., Vol. 167,pp.1220-1223, 1993.
|
|
|
| 16 |
R.S Leclercq, J.Dutka-Malen , Duval and P Courvalin., “Vancomycin resistance gene VanC is specific to Enterococcus gallinarum”,Antimicrob. Agents Chemother. , Vol.36,pp 2005-2008, 1992.
|
|
|
| 17 |
P.E.Reynolds and P. Courvalin , “Vancomycin resistance by synthesis of precursor terminating in D-alanyl D-alanine”. Antimicrobial Agents and chemother., Vol.49,pp.21- 5,2005.
|
|
|
| 18 |
F.Depardieu, P.E.Reynolds and P.Courvalin, “VanD type Vancomycin resistance Enterococcus faecium 10/96A.A”, Antimicrob. Agents chemother, Vol.47,pp.7-18 ,2003
|
|
|
| 19 |
B.Perichon, P.Reynolds and P.Courvalin, “VanD type glycopeptide resistant Enterococcus faecium B M 4339”, Antimicrob. Agents chemother, Vol. 41,pp.2016-2118, 1997.
|
|
|
| 20 |
M.Arthur and P. Courvalin, “Genetics and Mechanisms of glycopeptides resistance in enterococci”, Antimicrob Agents chemother, Vol.37,pp.1563-1571,1993.
|
|
|
| 21 |
T.D. Bugg , H.S. Dutka- malen , M. Arthur, P.Courvalin, and C.T. Walsh, “Identification of Vancomycin resistance protein vanA as a D-alanine ligase of altered substrate specificity”, Biochemistry , Vol.30, pp. 2017-2021, 1991.
|
|
|
| 22 |
M.Arthur, C.Mlinas, S. Dutka-Malen and P. Courvalin, “Structural relationship between the Vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenasesGene” , Vol.103 ,pp.133-134, 1991.
|
|
|
| 23 |
L.D.Gutmann, S.Billot-Klein, I.Al-Obeid,S.Klare,E.Francoual,Collatz and J van Heijenoort, “Inducible carboxypeptidase activity in Vancomycin–resistant enterococci”,Antimicrob. Agents Chemother, Vol.36,pp.77-80 ,1992 .
|
|
|
| 24 |
L. L.Carias, S D Rudin, C.J. Donskey and L.B. Rice, “Genetic linkage and cotransfer of a novel Van B-containing Transposon (Tn 5382) and alow-affinity penicillin-binding protein gene in a clinical Vancomycin resistant Enterococcus faecium is late” ,J. Bacteriol , Vol.180,pp.4426-4434,1998.
|
|
|
| 25 |
K.H.Dahl, G.S. Simonsen, O.Olsvik and A.Sundsfjord, “Heterogeneity in the vanB gene cluster of genomic ally diverse clinical strains of Vancomycin-resistant enterococci”, Antimicrob Agents Chemother, Vol.43,pp.1105-1110, 1999.
|
|
|
| 26 |
S.F. Altschul, W. Gish, W. Miller, E.W.Myers and D.J. Lipman, “Basic local alignment search tool”. J. Mol. Biol. Vol.215,pp.403-410, 1990.
|
|
|
| 27 |
http://www.ncbi.nlm.nih.gov/blast(December,2010)
|
|
|
| 28 |
http://www.ebi.ac.uk/clustalw (February,2011)
|
|
|
| 29 |
D.L. Headings, A.Herrera, E. Mazzi, and M. A. Bergman. “Fulminant neonatal septicemia caused by Streptococcus bovis”. J. Pediatr. , Vol.92,pp.282-283, 1978.
|
|
|
| 30 |
M.Falcone, F.Campanile ,M.Giannella ,S.Borbone,S.Stefani ,M.Venditti, “Staphylococcus haemolyticus endocarditis: clinical and microbiologic analysis of 4 cases”, Diagn.Microbiol. Infect .Dis. ,Vol.57(3),325-31, 2007.
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| Rajeshwari D Sanakal : Colleagues
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| Basappa B Kaliwal : Colleagues
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