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Vancomycin Resistance Genes in Various Organisms- An Insilico Study
Rajeshwari D Sanakal, Basappa B Kaliwal
Pages - 111 - 129     |    Revised - 01-05-2011     |    Published - 31-05-2011
Volume - 5   Issue - 2    |    Publication Date - May / June 2011  Table of Contents
Vancomycin Resistant Genes, Sequence Analysis, Enterococci sp., Plasmodium sp.
Abstract Glycopeptide antibiotics are widely used to treat many serious infections caused by gram positive bacteria particularly, methicillin resistant Enterococci and Staphyllococcus sp. Emergence of commonly acquired resistance in bacterial pathogens has lead to clinical complications and threat to human health. The resistance in these organisms is conferred by several Van genes like VanA, VanB, VanD, VanC and VanM. Knowledge of presence of Van genes in various organisms was felt necessary prior to molecular investigation. Therefore, in this insilico study the DNA sequence information was used and screening was carried out for Van gene sequences. Results indicate that many pathogenic and non-pathogenic bacteria, fungal, viral and protozoan pathogens, other organisms like fishes, mammals possess Van like sequences. The present findings provide first hand information on extent of Vancomycin antibiotic resistance in many organisms and emphasize further investigation of the significance of these genes using molecular and bioinformatics tools to help minimize human sufferings.
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Dr. Rajeshwari D Sanakal
Post-Graduate Department of Biotechnology and Microbiology - India
Professor Basappa B Kaliwal
Karnatak University - India