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Inhibition of Aldose Activity by Essential Phytochemicals of Cymbopogon citratus (DC.) Stapf
Vyshali.P, K.J. Thara Saraswathi, Rajeshwari D Sanakal, B. B. Kaliwal
Pages - 257 - 267     |    Revised - 01-11-2011     |    Published - 15-12-2011
Volume - 5   Issue - 5    |    Publication Date - November / December 2011  Table of Contents
Aldose Reductase, Molecular Docking, Citral, Geraniol, Myrcene, Cymbopogon citratus
The ambiguity of whether aldose reductase, an enzyme of polyol pathway, is linked to diabetes and its complication has been receded based on the recent studies made on the inhibition of its (Aldose reductase) activity. In our current study, we have used an in silico approach (molecular docking) to analyze the effect of essential phytochemicals obtained from Cymbopogon citratus on the aldose reductase activity. C.citratus is grown extensively in tropical countries including India for perfumery and pharmaceuticals. The essential phytochemicals of C.citratus like Myrcene, Citral, and Geraniol have been used as ligand for the molecular docking analysis with Aldose reductase as receptor. The docking analysis showed Myrcene, with binding energy of -8.76 Kcal/mol is best amongst Citral and Geraniol which are having binding energies of -7.24 Kcal/mol and -7.93 Kcal/mol respectively for inhibiting the activity of Aldose reductase.
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Miss Vyshali.P
Department of Microbiology and Biotechnology, - India
Associate Professor K.J. Thara Saraswathi
Bangalore University, - India
Dr. Rajeshwari D Sanakal
Karnatak University,Dharwad - India
Professor B. B. Kaliwal
Karnatak University,Dharwad - India