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A Computational Drug Designing from Active Product of Herbal Plant Ochna Squarrosa to Relieve Menstrual Complexities
Aubhishek Zaman, Md. Arafat Hossain Khan
Pages - 38 - 46     |    Revised - 15-03-2012     |    Published - 16-04-2012
Volume - 6   Issue - 2    |    Publication Date - April 2012  Table of Contents
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KEYWORDS
Molecular Docking, Ochna Squarrosa, Estrogen Receptor, Isoflavone
ABSTRACT
Ochna squarrosa (Golden Champak), a Bangladeshi herbal plant known locally as Sheuri, has for long been used for treating menstrual complexities. Although in root decoction of the related species variants has been reported to contain active compound Ochnaflavone- a derivative of isoflavone- this chemical’s presence in O. squarrosa was far from confirmed. Furhtermore, the molecular mechanism of action of the chemical is yet to be identified. Here, we report the presence of Ochnaflavone in the plant. Moreover, our computational study reveals a plausible target protein where the active compound binds. This study confirms the basis of the traditional herbal practice and can be useful for further developing a synthetic drug. This in return will shift the current use of Ochnaflavone as ‘observational medicine’ to ‘evidence based medicine’.
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Mr. Aubhishek Zaman
University of Dhaka - Bangladesh
aubhishek@gmail.com
Mr. Md. Arafat Hossain Khan
Jagannath University - Bangladesh