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Development of on Chip Devices for Life Science Applications
Stephanus  Buttgenbach, Anne Balck, Stefanie Demming, Claudia Lesche, Monika Michalzik, Alaaldeen
Pages - 148 - 158     |    Revised - 05-05-2009     |    Published - 18-05-2009
Volume - 3   Issue - 2    |    Publication Date - April 2009  Table of Contents
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KEYWORDS
Microfluidics, Biosensors, Bioreactors, micropumps
ABSTRACT
This work reports on diverse technologies implemented for fabricating microfluidic devices such as biomedical micro sensors, micro pumps, bioreactors and micro separators. UV depth lithography and soft lithography were applied in the fabrication processes using different materials, for example SU-8, polydimethylsiloxane (PDMS), silicon, glass and ceramics. Descriptions of the fabrication process of completed devices and their performance are provided. Experimental tests and results are presented where available. This work highlights the importance of down scaling in producing efficient devices suitable for life science applications using diverse materials that are compatible with chemical and biomedical applications.
CITED BY (12)  
1 Leester-Schädel, M., Lorenz, T., Jürgens, F., & Richter, C. (2016). Fabrication of Microfluidic Devices. In Microsystems for Pharmatechnology (pp. 23-57). Springer International Publishing.
2 Gothsch, T., Richter, C., Beinert, S., Schilcher, C., Schilde, C., Büttgenbach, S., & Kwade, A. (2016). Effect of cavitation on dispersion and emulsification process in high-pressure microsystems (HPMS). Chemical Engineering Science, 144, 239-248.
3 Gothsch, T., Schilcher, C., Richter, C., Beinert, S., Dietzel, A., Büttgenbach, S., & Kwade, A. (2015). High-pressure microfluidic systems (HPMS): flow and cavitation measurements in supported silicon microsystems. Microfluidics and Nanofluidics, 18(1), 121-130.
4 Al-Halhouli, A. A., Demming, S., Alahmad, L., LIobera, A., & Büttgenbach, S. (2014). An in-line photonic biosensor for monitoring of glucose concentrations. Sensors, 14(9), 15749-15759.
5 Al-Halabi, L., Balck, A., Michalzik, M., Fröde, D., Büttgenbach, S., Hust, M., ... & Dübel, S. (2013, January). Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor. In MAbs (Vol. 5, No. 1, pp. 140-149). Taylor & Francis.
6 Lorenz, T., Al-Halhouli, A. T., Mohsen, M., Matar, M., Büttgenbach, S., & Dietzel, A. (2013). Entwicklung und Simulation passiver Mikromischer für Strömungen im Bereich niedriger Reynolds-Zahlen. Mikrosystemtechnik 2013.
7 Boese, C., Dietzel, A., & Büttgenbach, S. (2013). Multifunktionaler Werkzeugwechsler für den Einsatz in mikrotechnischen Prozessketten–Messen, Prüfen, Montieren. Mikrosystemtechnik 2013.
8 A.B. Mattos, T.A. Freitas, V.L. Silva, R.F. Dutra, “A Dual Quartz Crystal Microbalance For Human Cardiac Troponin T In Real Time Detection”, Sensors and Actuators B: Chemical, 161(1), pp. 439–446, January 2012.
9 Bu¨ttgenbach, S. (2010, January). Numerical Analysis of Mixing in a Multifunction Electromagnetic Micropump. In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting (pp. 1299-1302). American Society of Mechanical Engineers.
10 Al-Halhouli, A. T. (2010, February). Analysis on the effect of geometrical design parameters on maximum shear stresses in an electromagnetic micropump. In MOEMS-MEMS (pp. 759315-759315). International Society for Optics and Photonics.
11 A. T. Al-Halhouli, A. Waldschik, M. I. Kilani, S. Büttgenbach: “Gentle Micropump Based on Microelectromagnetic Actuator” NSTI Nanotech, 2(2010), pp. 340-343, June 2010.
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Professor Stephanus  Buttgenbach
- Germany
Mr. Anne Balck
- Germany
Miss Stefanie Demming
- Germany
Miss Claudia Lesche
- Germany
Dr. Monika Michalzik
- Germany
Mr. Alaaldeen
- Germany
ala_t25@yahoo.com