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Whole Universe System, Optimal Exploration Methodology, Scientific Computing, Historically Statistical Analysis, Inverse Design of Universe System, Inexhaustible Explorations and Limited Explorations.

In allusion to problem of coming true the human’s final objective of scientific exploratory researches, this paper presented a new concept: the optimal methodology for human to explore whole universe. Based on the scientific computing of substance running process in whole universe system, as well as historically statistical summary of traditional natural science researches, this paper discovered that the traditional nature sciences are unoptimizable methodologies to explore whole universe, because nature sciences can just research on external phenomena which can be envisioned or guessed or measured by all possible means and equipments of sciences and technologies, although these nature sciences are just partially optimal methodologies to specially explore the substance phenomena in the existent and developing environments of human.